Pharmacogenomics and Heart Failure: Tailor‐Made Therapy?
نویسندگان
چکیده
منابع مشابه
Gene Therapy Targets and the Role of Pharmacogenomics in Heart Failure
Heart failure is supposed to be one of the most important causes of morbidity and mortality in the developed countries (McMurray JJ, 2000) (Cowie MR, 2000). It is not a disease by itself but it is a consequent condition of a number of co-existing factors including arterial hypertension, coronary artery heart disease and myocardiopathies. The quality of life of the patient is affected in heart f...
متن کاملPharmacogenomics of heart failure -- focus on drug disposition and action.
Heart failure represents the composite endpoint of various cardiovascular disorders. Advanced pharmacotherapy resulted in significant improvement of overall survival, however with highly variable outcome, possibly due to genetic modification of drug disposition and action. This review highlights the role of genetic polymorphisms in systems responsible for disposition of drugs, used in heart fai...
متن کاملTailoring therapy for heart failure: the pharmacogenomics of adrenergic receptor signaling
Heart failure is one of the leading causes of mortality in Western countries, and β-blockers are a cornerstone of its treatment. However, the response to these drugs is variable among individuals, which might be explained, at least in part, by genetic differences. Pharmacogenomics is the study of genetic contributions to drug response variability in order to provide evidence for a tailored ther...
متن کاملPharmacogenomics of Adrenergic Receptors; from Hypertension to Heart Failure
Cardiovascular medicine is a leading area of pharmacogenomics (PGx). A number of PGx studies have linked genetic polymorphisms to patients’ response to the drugs in the pharmacotherapy against cardiovascular diseases. Among them, PGx of adrenoceptors is one of the most important fields, because adrenergic networks play important roles in cardiovascular systems. The excess of adrenergic stimuli ...
متن کاملPharmacogenomics of beta1-adrenergic receptor polymorphisms in heart failure.
The major pathologic beta(1)-adrenergic receptor (beta(1)-AR) subtype in heart failure is beta(1)-AR. The authors' laboratory has thus pursued genetic variation of the beta(1)-AR gene at the molecular, cellular, physiologic, and clinical levels as the potential basis for interindividual variability in the response to beta-blocker treatment during heart failure. This article reviews these findin...
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ژورنال
عنوان ژورنال: Congestive Heart Failure
سال: 2004
ISSN: 1527-5299,1751-7133
DOI: 10.1111/j.1527-5299.2004.00301.x